Bioregulatory
Systems Medicine
Model

The model represents a consensus understanding of the fundamental elements of BrSM and the unique relationships between those elements. A group conceptualization method was used to aggregate the perspectives of the experts systemically.

The BrSM approach is driven by stimulating resolution processes

The BrSM model represents a consensus understanding of the core elements fundamental to Bioregulatory Systems Medicine and the unique relationships between those elements, as derived from the individual perspectives of medical scientific experts, clinicians, and organizational leaders and strategists.  A group conceptualization method, group concept mapping, was used to aggregate systematically the perspectives of these individuals to produce the resultant model.  A fundamental outcome of the model development process is the concept that the bioregulatory approach is driven by the goal of stimulating resolution processes through consideration of the communication and information pathways of the human organism.

The BrSM model consists of ten distinct yet related concepts

In the following sections, the core elements of the BrSM model are described as they are considered in ten distinct yet related concepts. These concepts emerged through confirmation with international medical scientific experts and clinicians, verification in scientific literature and research, and utilization of the concept mapping methodology.  The primary implications of the model content are discussed, areas for future inquiry are highlighted, and the model is positioned in a way that can potentially close the gap between the current medical paradigm and desired medical outcomes.

Biological Communication across Multi-Scale Networks

Bioregulatory Systems Medicine embraces the complexity of the biological networks in treating disease.

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Autoregulation of Biological Networks

Human health and disease are driven by the molecular regulatory information flow that propagates across biological autoregulatory networks.

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Biological Communication at the Microenvironment-Scale

The cellular microenvironment plays a fundamental role in disease by coupling signals from endogenous cellular and environmental stressors.

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Physiology of inflammation 

Inflammation is a central regulatory mechanism for maintaining tissue homeostasis.

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Inflammatory Network Response to Perturbation

The human body has the ability to synthesize and control molecules that promote or resolve inflammation.

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Microenvironment Response to Inflammation

The microenvironment is directly involved in the initiation and resolution of inflammatory responses.

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Diagnostics and Therapeutic Strategy

The primary therapeutic objective in BrSM is the restoration of patient autoregulatory capacity.

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Clinical Focus on Dysregulation

Application of BrSM in clinical practice focuses on the identification of dysregulated autoregulatory networks.

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Bioregulatory Clinical Pharmacology

The BrSM model proposes wider use of multitarget medications rather than more exclusive reliance on single-target drugs.

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Patient Health-Disease Continuum

Health care practitioners must be equipped with multitarget interventions that are able to modify molecular networks that play a key role in disease progression.

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Clinical Application Model

BrSM is a comprehensive, innovative medical approach within systems medicine.

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